TITLE
Response to minoxidil in severe alopecia areata correlates with T lymphocyte stimulation.

AUTHOR
Fiedler-Weiss VC; Buys CM

ORGANISATION
Department of Dermatology, University of Illinois, College of Medicine, Chicago 60680.

SOURCE
Br J Dermatol 1987 Dec; 117 (6): 759-63

LANGUAGE OF ORIGIN
English

ABSTRACT
Mitogen-induced T cell blastogenesis was determined in 47 patients with severe alopecia areata, before and after treatment with topical 5% minoxidil, and compared with control values. The group of 36 responders, who demonstrated terminal hair regrowth, showed significantly increased lymphocyte stimulation with concanavalin A and PHA before treatment, which decreased towards control values following hair regrowth. Lymphocytes from non-responders showed no significant differences from controls either before or after treatment. The results suggest that enhanced T cell blastogenesis may predict the response of severe alopecia areata to topical 5% minoxidil therapy. (AUTHOR)

MJTR: Alopecia Areata IM. Lymphocyte Transformation DE. Minoxidil TU. T-Lymphocytes IM.

MNTR: Adolescence. Adult. Alopecia Areata DT. Autoantibodies AN. Child. Female. Human. Male. Middle Age. Minoxidil PD. Support, Non-U.S. Gov't. JOURNAL ARTICLE

RNUM: 0 (Autoantibodies); 38304-91-5 (Minoxidil)

GEOT: ENGLAND

IDEN: ISSN: 0007-0963. JOURNAL-CODE: AW0. ENTRY-DATE: 880309. JOURNAL-SUBSET: M. IM-DATE: 8805.

ACCE: 88107434