Sprironolactone is commonly used to treat high blood pressure. However it also acts as an anti-androgen by decreasing the production of testosterone by the adrenal glands and by preventing dihydrotestosterone from binding to its androgenetic receptor similar to the way in which Cyproterone Acetate and cimitidine also act. Like cimetidine and Cyproterone acetate the use of Spironolactone in men should be limited due to its feminizig effects.

Studies involving Spironolactone / Aldactone

STUDY: Low-dose spironolactone in the treatment of female hirsutism.

STUDY: Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial

STUDY: Reversal of andro-genetic alopecia in a male. A spironolactone effect?

STUDY: Anti-androgen therapy in the female

STUDY: Clinical applications of antiandrogens

STUDY: Treatment of androgenic disorders in women: acne, hirsutism, and alopecia.

STUDY: Spironolactone directly inhibits proliferation of cultured human facial sebocytes and acts antagonistically to testosterone and 5 alpha-dihydrotestosterone in vitro.

STUDY: Antiandrogenic effects of topically applied spironolactone on the hamster flank organ.

STUDY: Comparison of sequential cyproterone acetate/estrogen versus spironolactone/oral contraceptive in the treatment of hirsutism.